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KMID : 1134819970260010130
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 1 p.130 ~ p.136
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Effects of Glutamine, Glycine and Nucleosides / Nucleotide Mixture on Intestinal Mucosal Growth in Rats
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Ly Sun-Yung
Oh Hyun-In
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Abstract
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Total parenteral nutritional effect was induced by surgical creation of Thiry-Vella fistula(TVFs) in rats. Glutamine, glycine or nucleosides/nucleotide mixture in solution was injected into the loops for 2, 4, 6, 8 days. Control animals received a 0.9% saline solution. Results include weight gain, total protein, DNA, [³H] thymidine incorporation into DNA, morphometry of the intestine in both TVFs and intestine in continuity. Perfusion of nucleosides/nucleotide mixture into the bypassed loops caused an increase in total protein, DNA content, villous height, villous surface area in loops. The injection of glycine into loops caused an increase in [³H] thymidine incorporation but the mean values of the protein and DNA contents were not significantly different from those in group Cont and group Nuc. Overall values for group Gln were slightly higher than those of the control but the differences were not statistically significant. This study suggests that this animal model may be useful for studying the effect of dietary factors on intestinal growth and maturation, separating the direct effect of diet from systemic effect on the intestine.
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KEYWORD
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Thiry-Vella fistula, nucleosides/nucleotide mixture / intestinal mucosa
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